Researchers in a 2025 meta-analysis combined the results of 21 studies and found that microfluidic sperm selection improved embryo quality and slightly improved fertilization rates, but it didn’t significantly improve euploid, pregnancy, or live birth rates.
In a 2025 study, the sperm selection device Zymot modestly improved blastocyst development compared with conventional sperm processing method (density gradient centrifugation) in donor egg cycles using frozen sperm, though fertilization rates were similar.
A 2024 randomized controlled trial (RCT) found that Zymot-selected sperm didn’t improve embryo euploidy rates, but increased fertilization rates. An important limitation of this study is that it was done in the general IVF population and not in individuals with high sperm DNA fragmentation.