A 2025 study showed that supplement use is widespread among IVF patients, with mixed impressions, limited evidence, and frequent confusion that leads many people to seek guidance from online communities rather than from clinical recommendations.
Lifestyle and egg quality
A pilot study in 2025 explored whether mitochondrial DNA mutations in follicular fluid could reflect egg quality, finding some early signs of a possible link, but there were some significant limitations.
A new study performed an “umbrella review” on the use of supplements for improving female infertility, finding that while studies show improvements in pregnancy outcomes, the quality of the data is low and “insufficient to recommend nutrient supplementation.”
Researchers in a 2023 study found that increasing female BMI resulted in decreased pregnancy and live birth rates after a single euploid transfer, while pregnancy loss rates increased. This effect was reduced in cases of male factor infertility only, suggesting that weight itself may not be responsible.
Researchers in a 2023 study compared fertility outcomes in women trying to conceive who took myo-inositol, probiotic and micronutrient supplements and found no improvements in clinical pregnancy and live birth rates, with contrasting outcomes in time-to-conception based on BMI.
