Researchers combined the results of 86 randomized trials to evaluate ten of the most commonly used IVF add-ons and found that endometrial scratching improved the chance of having a baby, while most other add-ons showed little or no benefit or require more high-quality research.
Researchers in a 2025 study found that women with RPL show distinct immune-related gene activity in their endometrium, identifying a possible molecular signature that could help diagnose or personalize treatment for RPL in the future.
Successful embryo implantation and pregnancy depends on careful control of the immune system. In this post, we’ll explore the general workings of the immune system and its role in pregnancy, examining how dysregulation of immune cells like natural killer (NK) cells and macrophages can impact fertility. Additionally, we’ll look into autoimmunity and discuss how immunotherapies may be used to improve IVF outcomes.
Researchers in 2024 detailed a case report of a patient with recurrent implantation failure as a result of bacterial contamination, which was resolved after removal of the zona.
