Researchers in a 2024 study found no health problems in children born from mosaic embryo transfers, with an average age of 3 years. They also found no differences in obstetric outcomes between mosaic and euploid transfers.
PGS Testing (PGT-A)
A 2024 study investigated the genetics of over 3,200 miscarriages, finding that two-thirds were associated with a chromosomal abnormality, with trisomy 16 and the 8p23.1 deletion as the most common abnormalities.
Researchers in a 2024 study compared the costs of patients with or without PGT-A, finding that patients younger than 35 may not benefit because of the higher chance of top-graded embryos being euploid anyway.
Researchers in a 2023 study compared PGT-A outcomes for patients with different diagnoses, including advanced maternal age (AMA), recurrent implantation failure (RIF), recurrent pregnancy loss (RPL) and severe male factor (SMF).
Researchers in a 2023 study found that arrested embryos have a high degree of aneuploidy, which is mainly due to mitotic errors that occur after fertilization. In a separate analysis of non-arrested embryos, they found that good quality/day 5 embryos have less aneuploidies compared to poor quality/day 6 and 7 embryos.
Researchers in a 2023 study found increased miscarriage rates with mosaic embryo transfers compared to euploids, with no differences in neonatal outcomes.
Researchers in a 2023 study combined the results of 74 studies to investigate what factors contribute to euploid live birth and miscarriage rates, identifying embryo quality, maternal age, specific diagnoses, repeat freeze/thaw, and other factors.
Researchers in a 2023 study evaluated factors affecting pregnancy outcomes after euploid transfer, and found that double euploid transfer, BMI, type of FET protocol, and the day of embryo biopsy all had an impact.
Evidence up to 2022 shows that a single PGT-A biopsy is highly concordant (similar) with the rest of the embryo when the embryo is aneuploid or euploid, but not when it’s mosaic or segmental.
Small studies find that some chaotic embryos can be euploid after PGT-A rebiopsy, while a case report details a live birth after the transfer of a chaotic embryo.
Researchers in a 2022 study examined the influence of paternal factors, such as semen parameters, paternal BMI and age, on aneuploidy.
Researchers in a 2022 study reported on the outcomes of 144 “abnormal” embryos, consisting of aneuploids and mosaics, finding a single live birth with an aneuploid and more favorable results with mosaics.
